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KMID : 1157520140100030135
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International Journal of Clinical Preventive Dentistry
2014 Volume.10 No. 3 p.135 ~ p.138
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Effect of Chelating Agents and Irrigants on Mineral Content of Root Canal Dentin: An In Vitro Study
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Keyur Pankaj Chande
Narendra U Manwar
Manoj G Chandak
Jyoti Lokade
Sneha R Chandak
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Abstract
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Objective: To evaluate and compare ex vivo the decalcifying effect of 17% ethylenediaminetetraacetic acid (EDTA), 15% cit-ric acid, 37% phosphoric acid and 5.25% sodium hypochlorite on root canal dentin.
Methods: Two 2-mm-thick slices were cut from the coronal third of the root of 24 human incisors. Each slice was sectioned into two equal parts. Specimens were assigned to one of four groups (n=24) for immersion in 20 ml of either 17% EDTA, or 15% citric acid, 37% phosphoric acid or 5.25% NaOCl, for three time periods (5, 10, and 15 minutes). The concentration of Ca2+ extracted from the dentine was measured by mass spectrophometry.The amount of calcium extracted was analysed us-ing the Kruskal-Wallis test for global comparisons and the Mann-Whitney U-test for pairwise comparisons.
Results: In the three time periods, 17% EDTA and 15% citric acid extracted the largest amount of calcium, with no sig-nificant differences between them. The 5.25% NaOCl solution extracted significant amounts of calcium, whereas 17% EDTA extracted 9.3 mg of the calcium in the first 5 min, and 15% citric acid and 37% phosphoric acid had a similar pattern of cal-cium removal (2.06 mg and 1.82 mg in first 5 minutes, respectively).
Conclusion: Solutions of 15% EDTA, 15% citric acid and 5% phosphoric acid decalcify root dentine, with most calcium ex-tracted during the first 5 minutes of action. The efficacy of 15% citric acid and 17% EDTA solutions was significantly greater than that of 37% phosphoric acid solution at each time period (5, 10 and 15 minutes).
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KEYWORD
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decalcification, citric acid, ethylenediaminetetraacetic acid, phosphoric acid, sodium hypochlorite, spectrophometry
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